Oxazolidinone Antibiotics Target the P Site on Escherichia coli Ribosomes

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Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes.

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Impact of P-Site tRNA and Antibiotics on Ribosome Mediated Protein Folding: Studies Using the Escherichia coli Ribosome

BACKGROUND The ribosome, which acts as a platform for mRNA encoded polypeptide synthesis, is also capable of assisting in folding of polypeptide chains. The peptidyl transferase center (PTC) that catalyzes peptide bond formation resides in the domain V of the 23S rRNA of the bacterial ribosome. Proper positioning of the 3' -CCA ends of the A- and P-site tRNAs via specific interactions with the ...

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tRNA binding sites on the subunits of Escherichia coli ribosomes.

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2002

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.46.4.1080-1085.2002